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Key facts

  • Viagra is used to treat erectile dysfunction (ED) in men.
  • ‘Viagra’ is a brand name, the active ingredient is ‘sildenafil’.
  • Starting dose is one 50mg tablet in 24 hours. Depending on results, adjust to 25mg or 100mg.
  • Take 30-60 minutes before sexual activity, usually lasts for 4 hours.
  • Large meals, fatty food, alcohol, and grapefruit can affect efficacy.
  • Studies show sildenafil is an effective and well-tolerated treatment for erectile dysfunction regardless of patient age, including men at least 75 years old.
  • See below for full list of side effects, cautions, and interactions with other drugs.

How does Viagra work?

Viagra works by increasing blood flow to the penis which helps men get and sustain an erection long enough for sex.

The active ingredient in Viagra is sildenafil, which is known medically as a PDE5 inhibitor. Sildenafil inhibits (blocks) an enzyme which regulates blood flow in the penis. PDE5 inhibitors multiply the natural process of arousal and increase blood flow to the penis in situations of sexual stimulation. Sildenafil helps to achieve an erection but relies on natural arousal as a trigger. It, and other PDE55 inhibitors such as tadalafil, vardenafil, and avanafil, support sexual relations when erections are failing.

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